CAR-T cell therapy for cancer causes “brain fog”
New research shows CAR-T cell therapy causes mild cognitive impairment via the same cellular mechanism as chemotherapy and respiratory infections like the flu and COVID-19. …
Colonic inflammation explains missing link between obesity and beta-cell proliferation
Colonic inflammation caused by obesity activates the hepatic ERK pathway, which increases β-cell proliferation and insulin production, revealing a new role of the gastrointestinal tract in controlling glucose homeostasis. …
Discovery explains long COVID breathing problems
Study reveals that COVID-19 survivors with persistent breathing issues have distinct immune system changes linked to lung damage severity, offering hope for targeted long COVID treatments. …
Psychedelics can reverse neuroimmune interactions that drive fear responses
New study finds that interactions between immune and brain cells drive fear responses, but treatment with psychedelics like MDMA and psilocybin may reverse these effects. …
Retinal clues for genetic susceptibility to schizophrenia
Researchers investigated whether genetic risk for schizophrenia is associated with changes in retinal nerve connections, as the retina is a direct extension of the brain and may reflect brain alterations related to the disorder. …
Metabolic syndrome sharply increases risk of breast cancer recurrence and subsequent death
New research has shown that, in survivors of breast cancer, having an unhealthy metabolic profile, also known as ‘metabolic syndrome,’ increases the risk of breast cancer recurrence by 69 percent and the risk of subsequent breast cancer mortality by 83 percent. …
Brain pathway links inflammation to loss of motivation, energy in advanced cancer
Preclinical study reveals that specific neurons connect cancer-related brain inflammation to loss of motivation in advanced cancer and that blocking this pathway can restore motivation. …
Immune molecules that fight infection also act on the brain, inducing anxiety or sociability
New research on the IL-17 cytokine adds to growing evidence that immune molecules can influence behavior during illness. …
A gentle approach offers new hope for inflammatory lung diseases
Scientists identified a protein that mitigates lung inflammation in pulmonary sarcoidosis by regulating white blood cells, and a clinical trial of its therapeutic form showed promising results. …
An immune cell may explain how maternal inflammation causes neurodevelopmental disorders
Researchers have identified a potential mechanism connecting maternal inflammation to delayed neurodevelopment in infants, highlighting the role of CD11c-positive microglia in brain development. …
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