Posts by University of California - San Diego
Genetic variation in individual brain cell types may predict disease risk
Major genetic risk allele for Alzheimer’s disease is linked to non-coding regions of the genome called enhancers that are selectively active in microglia, the major immune cell in the brain. …
Read Full ArticlePhage therapy shows promise for alcoholic liver disease
Gut bacteria toxin linked to worse clinical outcomes in patients with alcoholic liver disease; treatment with bacteriophages clears the bacteria and eliminates the disease in mice. …
Read Full ArticlePopular pain medication associated with greater risk of hypoglycemia
Tramadol, an opioid, is widely used to treat moderate or severe pain, but patients may be at risk of low blood sugar levels. …
Read Full ArticleAdding MS drug to targeted cancer therapy may improve glioblastoma outcomes
By reaching stem cells at the tumor’s root, multiple sclerosis drug teriflunomide, paired with targeted cancer therapy, markedly shrinks patient-derived glioblastomas grown in mice. …
Read Full ArticleResearchers map protein-gene interactions involved in Alzheimer’s disease
Researchers have identified changes in gene activity associated with Alzheimer’s disease. …
Read Full ArticleCancer scientists identify new drug target for multiple tumor types
A research team has identified an enzyme involved in remodeling the plasma membrane of multiple cancer cell types that is critical to both the survival of tumors and their uncontrolled growth. …
Read Full ArticleProtein clumps in ALS neurons provide potential target for new therapies
Researchers identified chemical compounds that prevent stress-induced TDP-43 protein accumulation in ALS motor neurons. …
Read Full ArticleEarly life exposure to nicotine alters neurons, predisposes brain to addiction later
Neonatal exposure to nicotine alters the reward circuity in the brains of newborn mice, increasing their preference for the drug in later adulthood, …
Read Full ArticleIt’s in the weeds: Herbicide linked to human liver disease
Glyphosate, the primary ingredient in Monsanto’s popular weed killer Roundup, has been linked to liver disease in animal models. …
Read Full ArticlePersonalized ‘Eye-in-a-Dish’ models reveal genetic underpinnings of macular degeneration
Researchers have recapitulated retinal cells in the lab using patient-derived stem cells. This “eye-in-a-dish” model allowed them to look for genetic variants that might contribute to AMD. …
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