CAR-T cell therapy for cancer causes “brain fog”
New research shows CAR-T cell therapy causes mild cognitive impairment via the same cellular mechanism as chemotherapy and respiratory infections like the flu and COVID-19. …
A protein link between brain diseases and leaky blood-brain barrier
Mutations in the TARDBP gene that lower TDP-43 protein levels damage brain blood vessel endothelial cells, disrupting the blood-brain barrier and contributing to diseases like Alzheimer’s, frontotemporal dementia, and ALS. …
Impaired synapse-clearing ability in macrophages linked to autism
A new study finds that macrophages from individuals with autism have a significantly impaired ability to clear synaptic proteins. …
Psychedelics can reverse neuroimmune interactions that drive fear responses
New study finds that interactions between immune and brain cells drive fear responses, but treatment with psychedelics like MDMA and psilocybin may reverse these effects. …
Retinal clues for genetic susceptibility to schizophrenia
Researchers investigated whether genetic risk for schizophrenia is associated with changes in retinal nerve connections, as the retina is a direct extension of the brain and may reflect brain alterations related to the disorder. …
Brain pathway links inflammation to loss of motivation, energy in advanced cancer
Preclinical study reveals that specific neurons connect cancer-related brain inflammation to loss of motivation in advanced cancer and that blocking this pathway can restore motivation. …
Brain’s dopamine system linked to psychosis risk in cannabis use disorder
Study finds that people with cannabis use disorder (CUD) have increased dopamine levels in a brain region associated with psychosis. …
Immune molecules that fight infection also act on the brain, inducing anxiety or sociability
New research on the IL-17 cytokine adds to growing evidence that immune molecules can influence behavior during illness. …
Could an arthritis drug provide lasting relief from epilepsy seizures?
A drug typically prescribed for arthritis halts brain-damaging seizures in a mouse model of chronic epilepsy. …
Boosting brain’s waste removal system improves memory in old mice
Rejuvenating the brain’s waste-removal system can enhance memory in aging mice, potentially offering a new approach to combat neurodegenerative diseases like Alzheimer’s and Parkinson’s. …
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