FGF21 hormone can reverse fatty liver disease
A pioneering research study details how the hormone FGF21 (fibroblast growth factor 21) can reverse the effects of fatty liver disease in mice. …
Colonic inflammation explains missing link between obesity and beta-cell proliferation
Colonic inflammation caused by obesity activates the hepatic ERK pathway, which increases β-cell proliferation and insulin production, revealing a new role of the gastrointestinal tract in controlling glucose homeostasis. …
Food as medicine: How diet shapes gut microbiome health
New research shows how a typical Western diet prevents the gut microbiome from recovering after antibiotic treatment and leaves it susceptible to infection. …
Reprogramming cancer cells to treat acute myelogenous leukemia
A new combination therapy alters gene activity to reduce stem cell-like traits and promote cell differentiation, offering potential therapeutic benefits for acute myelogenous leukemia (AML). …
An immune cell may explain how maternal inflammation causes neurodevelopmental disorders
Researchers have identified a potential mechanism connecting maternal inflammation to delayed neurodevelopment in infants, highlighting the role of CD11c-positive microglia in brain development. …
Boosting brain’s waste removal system improves memory in old mice
Rejuvenating the brain’s waste-removal system can enhance memory in aging mice, potentially offering a new approach to combat neurodegenerative diseases like Alzheimer’s and Parkinson’s. …
Gut bacteria promote healing of colon mucosa
The bacterium Clostridium scindens plays a crucial role in gut healing by converting primary bile acids, indicating potential therapeutic uses for ulcerative colitis and similar conditions. …
Breakthrough study reveals genetic mutation that could serve as basis for new rheumatoid arthritis treatment
New findings reveal that a specific mutation in a protein called TRAF1 can shut down an overactive immune response, dramatically reducing inflammation in mice and potentially paving the way for a new class of drugs to treat rheumatoid arthritis. …
Artificial sweetener aspartame triggers insulin spike leading to blood vessel inflammation in mice
New research conducted on mice indicates that aspartame, one of the most commonly used sugar substitutes, may affect vascular health. …
SSRI antidepressants can protect against infections and sepsis by regulating immune response
Scientists have discovered how SSRI antidepressants regulate the immune response and prevent sepsis in mice, demonstrating a potential new use for these popular drugs. …
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