CAR-T cell therapy for cancer causes “brain fog”
New research shows CAR-T cell therapy causes mild cognitive impairment via the same cellular mechanism as chemotherapy and respiratory infections like the flu and COVID-19. …
Heart rhythm disorder traced to bacterium causing gum disease
The gum disease bacterium Porphyromonas gingivalis can enter the bloodstream, infiltrate the heart, and quietly promote scar tissue buildup that distorts the heart’s structure, disrupts electrical signals, and increases the risk of atrial fibrillation. …
New targets for the treatment of pancreatic cancer
A newly discovered class of peptides expressed in pancreatic cancer cells could provide promising targets for T-cell therapies and other approaches to combat pancreatic tumors. …
Hypoglycemia contributes to eye damage and vision loss in diabetic retinopathy and an experimental drug may treat it
New findings indicate that hypoglycemia may cause breakdown of the blood-retinal barrier, providing new insights into the development of diabetic retinopathy in diabetes patients. …
An antibody drug dismantles a metabolic barrier to anti-tumor immunity
Researchers have identified a fat uptake mechanism in immune cells within tumors that suppresses anti-tumor immunity and have developed an antibody drug to overcome this barrier in cancer immunotherapy. …
Drug targets identified for pancreatic cancer
Simultaneous disruption of lipid metabolism and KRAS-MAPK signaling eliminates pancreatic cancer tumors in preclinical human and mouse models. …
Fatty acids promote immune suppression and therapy resistance in triple-negative breast cancer
New findings reveal a mechanism that enables triple-negative breast cancer to develop therapy resistance. …
Could an arthritis drug provide lasting relief from epilepsy seizures?
A drug typically prescribed for arthritis halts brain-damaging seizures in a mouse model of chronic epilepsy. …
Retinal degeneration: Researchers develop eye drops that slow vision loss in animals
Newly developed eye drops slow vision loss in animal models of retinitis pigmentosa, a group of inherited diseases that lead to progressive retinal degeneration. …
Synthetic cannabinoid compound harnesses cannabis’ pain-relieving properties without side effects
A newly developed synthetic cannabinoid compound mimics a natural molecule found in the cannabis plant, harnessing its pain-relieving properties without causing addiction or mind-altering side effects in mice. …
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