Posts by University of Pennsylvania School of Medicine
Global trial shows CAR T-cell therapy can lead to durable remissions in non-Hodgkin’s lymphoma
In an update to a global clinical trial stretching from Philadelphia to four continents, the chimeric antigen receptor (CAR) T cell therapy Kymriah® …
Read Full ArticleBeing older helps skin heal with less scarring, and now researchers know why
A compound secreted in the bloodstream could be the key factor that causes wounds in older people to heal with less scarring than in younger people. The compound is called stromal cell-derived-factor-1 (SDF1), …
Read Full ArticleDNA vaccine leads to immune responses in HPV-related head and neck cancer
A therapeutic vaccine can boost antibodies and T cells, helping them infiltrate tumors and fight off human papillomavirus (HPV)-related head and neck cancer. Researchers from the Abramson Cancer Center …
Read Full ArticleAdditional inhibitor can help anti-VEGF therapy overcome resistance in deadly brain cancer
Adding another inhibitor to therapies that cut off a tumor’s access to blood vessels could be the key to helping those therapies overcome resistance in glioblastoma, a deadly form of brain cancer. …
Read Full ArticleCandidate for universal flu vaccine protects against multiple strains
A universal flu vaccine that protects people against most influenza strains is one step closer to reality, with a study from the Perelman School of Medicine at the University of Pennsylvania. …
Read Full ArticleGreening vacant lots reduces feelings of depression in city dwellers, study finds
Greening vacant urban land significantly reduces feelings of depression and improves overall mental health for the surrounding residents, researchers from the Perelman School of Medicine and the School of Arts & Sciences …
Read Full ArticleStudy reveals new therapeutic target for slowing the spread of flu virus
Influenza A (flu A) hijacks host proteins for viral RNA splicing and blocking these interactions caused replication of the virus to slow, according to new research published in Nature Communications …
Read Full ArticleDepleted metabolic enzymes promote tumor growth in kidney cancer
Kidney cancer, one of the ten most prevalent malignancies in the world, has increased in incidence over the last decade, likely due to rising obesity rates. The most common subtype of this cancer is “clear cell” renal cell carcinoma …
Read Full ArticleT cell biomarker predicts which CLL patients will respond to CAR T cell therapy
Penn Medicine researchers may have found the reason why some patients with advanced chronic lymphocytic leukemia (CLL) don’t respond to chimeric antigen receptor (CAR) T cell therapy, and the answer is tied to how …
Read Full ArticlePotential of manipulating gut microbiome to boost efficacy of cancer immunotherapies
The composition of bacteria in the gastrointestinal tract may hold clues to help predict which cancer patients are most apt to benefit from the personalized cellular therapies …
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