Posts by University of Pennsylvania School of Medicine
Depleted metabolic enzymes promote tumor growth in kidney cancer
Kidney cancer, one of the ten most prevalent malignancies in the world, has increased in incidence over the last decade, likely due to rising obesity rates. The most common subtype of this cancer is “clear cell” renal cell carcinoma …
Read Full ArticleT cell biomarker predicts which CLL patients will respond to CAR T cell therapy
Penn Medicine researchers may have found the reason why some patients with advanced chronic lymphocytic leukemia (CLL) don’t respond to chimeric antigen receptor (CAR) T cell therapy, and the answer is tied to how …
Read Full ArticlePotential of manipulating gut microbiome to boost efficacy of cancer immunotherapies
The composition of bacteria in the gastrointestinal tract may hold clues to help predict which cancer patients are most apt to benefit from the personalized cellular therapies …
Read Full ArticleProtective ‘epigenetic landscape’ of normal aging is impaired in Alzheimer’s disease
Although certain genetic variants increase the risk of Alzheimer’s disease (AD), age is the strongest known risk factor. But the way in which molecular processes of aging predispose people to AD, or become impaired in AD remains a mystery. …
Read Full ArticlePast exposures shape immune response in pediatric acute respiratory infections
Acute respiratory tract infections (ARTI) are the leading global cause of death in early childhood, according to the Centers for Disease Control and Prevention (CDC). …
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