New study reveals that people with celiac disease have subtle but consistent differences in immune cell function, particularly in CD4 helper T cells, suggesting that autoimmune risk involves altered immune cell behavior. …
A new type of cancer immunotherapy links immune cells to tumor cells by targeting a tumor protein and an immune cell marker, activating the immune system to destroy advanced solid tumors. …
Researchers discovered a mitochondrial checkpoint that functions as a metabolic switch, enabling dendritic cells to effectively activate T cells to fight viruses and tumors. …
In a Phase 2 study, pembrolizumab showed a modest response rate in rare cancers, and certain features of the tumor microenvironment were found to better predict immunotherapy response than genomic analysis alone. …
Two companion studies show that mezigdomide can reverse T cell exhaustion and improve the effectiveness of CAR T-cell therapy and bispecific antibody treatments, which are already transforming the standard of care for multiple myeloma. …
New research highlights a promising platform for next-generation CAR T-cell therapies that can achieve complete responses at low doses. …
Eating induces a temporary metabolic state that enhances the function and metabolic activity of T cells, potentially improving immune responses and the effectiveness of T cell–based therapies. …
A new study suggests that the organization of immune cells within melanoma tumors may help identify which patients will benefit from combination immunotherapy after standard anti-PD-1 treatment fails. …
mRNA vaccines can trigger strong anti-tumor immune responses through an unexpected immune cell mechanism. …
Research shows that the amino acid cysteine promotes the production of the antioxidant glutathione, which regulates T-cell activity, and also supports T-cell proliferation and maintenance of their cancer-fighting function. …
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