Stem cell memory CAR T-cells achieve complete remissions at low doses without chemotherapy preconditioning
New research highlights a promising platform for next-generation CAR T-cell therapies that can achieve complete responses at low doses. …
How eating primes immune cells for future responses
Eating induces a temporary metabolic state that enhances the function and metabolic activity of T cells, potentially improving immune responses and the effectiveness of T cell–based therapies. …
Tumor cellular neighborhoods predict melanoma response to combination immunotherapy
A new study suggests that the organization of immune cells within melanoma tumors may help identify which patients will benefit from combination immunotherapy after standard anti-PD-1 treatment fails. …
mRNA vaccines follow unconventional immune path to destroy tumors
mRNA vaccines can trigger strong anti-tumor immune responses through an unexpected immune cell mechanism. …
Amino acid cysteine fuels cancer-fighting T cells
Research shows that the amino acid cysteine promotes the production of the antioxidant glutathione, which regulates T-cell activity, and also supports T-cell proliferation and maintenance of their cancer-fighting function. …
Gut primes pathogenic T cells responsible for neuroinflammation in multiple sclerosis
Researchers identify the role of gut-derived cells in antigen presentation as a key initiator of autoimmune neuroinflammation. …
Scientists “turbocharge” immune cells to attack prostate cancer
A new class of engineered, supercharged T cells is stronger, longer-lasting, and more precise at killing prostate cancer cells by fine-tuning how they physically interact with tumor cells. …
Glioblastoma brain tumors hijack sugar metabolism to evade immune attack
Study finds immune cells in glioblastoma use fructose to evade immune response, pointing to a new treatment target. …
Universal vaccine may provide broad protection against many respiratory infections and allergens
A newly developed universal vaccine formula, delivered intranasally, protects against a wide range of respiratory viruses, bacteria, and even allergens in preclinical studies. …
Cancer treatment: Optimization of CAR T-cell therapy
Researchers improve the efficacy of CAR T-cell therapy in solid tumors by modifying T cells to make them resistant to local inhibition within the tumor microenvironment. …
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