Epigenomic analysis sheds light on risk factors for ALS
In a study of cells from nearly 400 ALS patients, researchers identified genomic regions with chemical modifications linked to disease progression. …
Circadian rhythms can influence drug metabolism and efficacy
Circadian variations in liver function play an important role in how drugs are broken down in the body. …
A protein found in human sweat may protect against Lyme disease
Researchers have discovered a protective protein against Lyme disease in human sweat, with approximately one-third of the population carrying a genetic variant associated with the tick-borne disease. …
How early-stage colorectal cancer cells hide from the immune system
During the early stages of colorectal cancer development, activation of the SOX17 gene can render cells essentially invisible to the immune system, thereby facilitating colorectal cancer progression. …
Vaccine delivers a boost to T cell therapy
Vaccine boosting may enable engineered T cells to eradicate solid tumors such as glioblastoma. …
Gene-editing technique could speed up study of cancer mutations
Researchers have developed a way to easily engineer specific cancer-linked mutations into mouse models, which will help identify and test new drugs that target these mutations. …
Microneedle vaccine printer could help vaccines reach more people
A newly developed vaccine printer generates vaccine-filled microneedle patches that can be stored long-term at room temperature and applied to the skin. …
Neuroscientists identify neurons especially vulnerable to degeneration in Alzheimer’s disease
Neuroscientists have identified a subset of neurons within the mammillary body of the hypothalamus that are most susceptible to degeneration in Alzheimer’s disease. …
Immunostimulatory prodrugs provoke immune response against tumors but avoid side effects
Study shows that immunostimulatory prodrugs tuned for optimal activation timing provoke the immune system to attack tumors without producing systemic inflammation. …
Molecules found in mucus could prevent cholera infection
Molecules found in mucus can block cholera infection by interfering with the genes that cause the microbe to switch into a harmful state. …
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