Posts by Brigham and Women's Hospital
New technique predicts which melanoma patients are at risk for metastatic recurrence
Primary melanoma patients with lower T-cell fraction are 2.5 times more likely to have cancer metastasize than patients with higher T-cell fraction. …
Read Full ArticleNanoparticle therapeutic restores tumor suppressor, sensitizes cancer cells to treatment
In preclinical experiments, investigators restored tumor suppressor p53 using synthetic mRNA nanoparticles, making cancer cells susceptible to available cancer drugs. …
Read Full ArticleHear this: Healthful diet tied to lower risk of hearing loss
Adherence to diets such as dietary approaches to stop hypertension (DASH) and alternate mediterranean (AMED) diet associated with lower risk of hearing loss. …
Read Full ArticleChromosomal abnormalities uncovered in many couples struggling with recurrent miscarriage
Genetic sequencing may help identify patients at increased risk of subsequent miscarriages who may benefit most from personalized intervention. …
Read Full ArticlePredicting risk of heart failure for diabetes patients with help from machine learning
Investigators used artificial intelligence to identify top 10 variables that can predict, with a high degree of accuracy, future heart failure among patients living with diabetes. …
Read Full ArticleNovel combination of drugs may overcome drug-resistant cancer cells
Mathematical modeling and preclinical experiments suggest that time-sensitive administration of glucose-6-phosphate dehydrogenase inhibitors alongside other drugs may thwart resistance in cancer cells. …
Read Full ArticleA new role for genetics in cancer therapy-induced cardiomyopathy
Recent advances in the development of cancer therapies have increased long-term survival and prognosis. However, the increased burden and prevalence of harmful side effects, including cardiomyopathy, …
Read Full ArticleSmoking cessation may reduce risk of rheumatoid arthritis
Smoking is an important risk factor for developing the most common form of rheumatoid arthritis (RA) and other inflammatory diseases, …
Read Full ArticleA combinatorial microRNA strategy to defeat glioblastoma
In cancer therapeutics research, microRNAs–tiny strings of nucleotides that get churned out inside cells–have been a source of both excitement and disappointment. …
Read Full ArticleHome-based hypertension management program produces ‘striking’ results
Pilot study by Brigham investigators finds that an innovative care-delivery program helped 81 percent of participants achieve blood pressure control in seven weeks. …
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