Scientists have identified a resistance mechanism to CDK4/6 inhibitors in metastatic breast cancer and proposed a novel treatment strategy to overcome it. …
The presence of relatively high numbers of immune cells known as monocytes in tumors is linked to better outcomes in esophageal cancer patients treated with a combination of chemotherapy and immunotherapy. …
A multi-center study found that fecal microbiota transplants (FMT) from healthy donors are safe and show promise in improving response to immunotherapy in patients with advanced melanoma. …
Scientists use a gastric organoids model to show that cancer cells-to-be accumulate a series of specific genetic changes in a predictable and sequential way years before they are identifiable as pre-malignancies. …
Vaccine boosting may enable engineered T cells to eradicate solid tumors such as glioblastoma. …
A Tumor Metabolism Atlas that catalogs gene activity and the levels of metabolites in tumor samples offers a new way of identifying cancer mechanisms. …
Researchers working with animal models have discovered that neurons located in distant areas of the brain can activate specific genes in glioblastoma, which promotes tumor infiltration into surrounding tissues. …
Postmenopausal women with polycystic ovary syndrome (PCOS) are more than twice as likely to be diagnosed with ovarian cancer. …
Single-cell transcriptomic and epigenomic profiling of neuroblastoma bone marrow metastases provides the basis for new therapeutic approaches against this childhood cancer. …
Using 3-D models of ovarian cancer tumors, scientists have shown that a cancer cell’s location and environment within a tumor can strongly influence gene activity and the cell’s role in the cancer’s biology. …
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