Drug targets identified for pancreatic cancer
Simultaneous disruption of lipid metabolism and KRAS-MAPK signaling eliminates pancreatic cancer tumors in preclinical human and mouse models. …
Psychedelics can reverse neuroimmune interactions that drive fear responses
New study finds that interactions between immune and brain cells drive fear responses, but treatment with psychedelics like MDMA and psilocybin may reverse these effects. …
Children face elevated kidney, heart, and gut risks for years after COVID-19 infection
Long COVID can result in increased risk for a variety of serious health problems for young people, including those affecting the kidney, gut, and cardiovascular system. …
Retinal clues for genetic susceptibility to schizophrenia
Researchers investigated whether genetic risk for schizophrenia is associated with changes in retinal nerve connections, as the retina is a direct extension of the brain and may reflect brain alterations related to the disorder. …
Reprogramming cancer cells to treat acute myelogenous leukemia
A new combination therapy alters gene activity to reduce stem cell-like traits and promote cell differentiation, offering potential therapeutic benefits for acute myelogenous leukemia (AML). …
Metabolic syndrome sharply increases risk of breast cancer recurrence and subsequent death
New research has shown that, in survivors of breast cancer, having an unhealthy metabolic profile, also known as ‘metabolic syndrome,’ increases the risk of breast cancer recurrence by 69 percent and the risk of subsequent breast cancer mortality by 83 percent. …
Largest ever genome-wide association study uncovers new drug targets and potential therapies for osteoarthritis
A combined study of genetic data from nearly 2 million people—including about 500,000 with osteoarthritis and 1.5 million controls—found 962 genetic markers linked to the condition, 513 of which were new. …
Study sheds light on how inherited cancer mutations drive tumor growth
A proteogenomic analysis of over 1,000 cancer patients revealed that inherited cancer mutations lead to dysfunctional proteins that disrupt physiological functions, providing insights into individual cancer risk and strategies for prevention, early detection, and treatment. …
New key genes in Parkinson’s disease identified using CRISPR technology
Researchers employed CRISPR interference technology to systematically examine every gene in the human genome, discovering new genes linked to Parkinson’s disease that could lead to novel therapeutic targets. …
Brain pathway links inflammation to loss of motivation, energy in advanced cancer
Preclinical study reveals that specific neurons connect cancer-related brain inflammation to loss of motivation in advanced cancer and that blocking this pathway can restore motivation. …
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