FGF21 hormone can reverse fatty liver disease
A pioneering research study details how the hormone FGF21 (fibroblast growth factor 21) can reverse the effects of fatty liver disease in mice. …
CAR-T cell therapy for cancer causes “brain fog”
New research shows CAR-T cell therapy causes mild cognitive impairment via the same cellular mechanism as chemotherapy and respiratory infections like the flu and COVID-19. …
Heart rhythm disorder traced to bacterium causing gum disease
The gum disease bacterium Porphyromonas gingivalis can enter the bloodstream, infiltrate the heart, and quietly promote scar tissue buildup that distorts the heart’s structure, disrupts electrical signals, and increases the risk of atrial fibrillation. …
Colonic inflammation explains missing link between obesity and beta-cell proliferation
Colonic inflammation caused by obesity activates the hepatic ERK pathway, which increases β-cell proliferation and insulin production, revealing a new role of the gastrointestinal tract in controlling glucose homeostasis. …
New targets for the treatment of pancreatic cancer
A newly discovered class of peptides expressed in pancreatic cancer cells could provide promising targets for T-cell therapies and other approaches to combat pancreatic tumors. …
Enhanced CAR T cell therapy offers new strategy for lymphoma
A next-generation CAR T cell therapy showed promising results in a small study of patients whose B-cell lymphomas continued to resist multiple rounds of other cancer treatments, including commercially available CAR T cell therapies. …
Hypoglycemia contributes to eye damage and vision loss in diabetic retinopathy and an experimental drug may treat it
New findings indicate that hypoglycemia may cause breakdown of the blood-retinal barrier, providing new insights into the development of diabetic retinopathy in diabetes patients. …
Discovery explains long COVID breathing problems
Study reveals that COVID-19 survivors with persistent breathing issues have distinct immune system changes linked to lung damage severity, offering hope for targeted long COVID treatments. …
Lactate mediates the training of innate immune defenses
Lactate production by immune cells drives trained immunity via an epigenetic mechanism. …
A protein link between brain diseases and leaky blood-brain barrier
Mutations in the TARDBP gene that lower TDP-43 protein levels damage brain blood vessel endothelial cells, disrupting the blood-brain barrier and contributing to diseases like Alzheimer’s, frontotemporal dementia, and ALS. …
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