A bioengineered factory for T-cells
Scientists have developed an injectable sponge-like gel that enhances the production T-cells after a bone marrow transplant, increasing the quantity and diversity of these key components of the immune system. …
Improving the body’s ability to fight cancer and intruders
The human body’s immune system is like a vast team of special agents. Certain cells called T cells each individually specialize in recognizing a particular intruder, such as the influenza virus or salmonella. …
FGL2 protein may be an effective target for glioblastoma
Researchers at The University of Texas MD Anderson Cancer Center have discovered an immune regulator that appears to dictate glioblastoma (GBM) progression …
Scientists create a renewable source of cancer-fighting T cells
A study by UCLA researchers is the first to demonstrate a technique for coaxing pluripotent stem cells — which can give rise to every cell type in the body and which can be grown indefinitely in the lab …
Fever alters immune cells so they can better reach infections
Fever is known to help power up our immune cells, and scientists in Shanghai have new evidence explaining how. They found in mice that fever alters surface proteins on immune cells like lymphocytes …
Engineered T cells promote long-term organ transplant acceptance
Organ transplant rejection is a major problem in transplantation medicine. Suppressing the immune system to prevent organ rejection, however, opens the door to life-threatening infections. …
Unconventional immune cells trigger disturbed cytokine production in human spondyloarthritis
Spondyloarthritis is one of the most common types of chronic joint inflammation affecting nearly 1-2% of the Western population. Cytokine blockade of Tumor necrosis factor (TNF) …
Mechanism for impaired allergic inflammation in infants may explain hygiene hypothesis
The hygiene hypothesis may explain why asthma and other allergic airway diseases have dramatically increased over the past decades in industrialized countries. The hypothesis suggests that decreased exposure to microbial …
Stopping cancer from recruiting immune system double agents
Cancerous tumors trick myeloid cells, an important part of the immune system, into perceiving them as a damaged part of the body; the tumors actually put myeloid cells to work helping them grow and metastasize …
Vaccine, checkpoint drugs combination shows promise for pancreatic cancers
Researchers at the Johns Hopkins Kimmel Cancer Center discovered a combination of a cancer vaccine with two checkpoint drugs reduced pancreatic cancer tumors in mice, …
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