Breast cancer: The risks of brominated flame retardants
Mammary gland of a prepubescent female rat stained to see its development. Credit: Isabelle Plante (INRS)
Brominated flame retardants (BFRs) are found in furniture, electronics, and kitchenware to slow the spread of flames in the event of a fire. However, new research has shown that these molecules may lead to premature mammary gland development, which is linked to an increased risk of breast cancer. The study by Professor Isabelle Plante from the Institut National de la Recherche Scientifique (INRS) made the cover of the February issue of the journal Toxicological Sciences.
BFRs are considered to be endocrine disruptors due to their ability to interfere with the hormonal system. Since they are not directly bound to the material in which they are added, the molecules escape easily to the environment. They are then found in house dust, air and food.
This exposure can cause problems for mammary glands because their development is highly regulated by hormones. “BFRs pose a significant risk, particularly during sensitive periods, from intrauterine life to puberty and during pregnancy,” says Professor Plante, co-director of the Intersectoral Centre for Endocrine Disruptor Analysis and environmental toxicologist. Endocrine disruptors, such as BFRs, can mimic hormones and cause cells to respond inappropriately.
The effects of environmental exposure
In their experiments, the research team exposed female rodents to a mixture of BFRs, similar to that found in house dust, prior to mating, during gestation and during lactation. Biologists were able to observe the effects on the offspring at two stages of development and on the mothers.
In pre-pubertal rats, the team noted premature development of mammary glands. For pubescent rats, the results, published in 2019, showed deregulation of communication between cells. Similar consequences were observed in lactating female rats in a 2017 study. All of these effects are associated with an increased risk of breast cancer.
Professor Isabelle Plante points out that peaks in human exposure to BFRs have been observed in the early 2000s. “Young women exposed to BFRs in utero and through breastfeeding are now in the early stages of fertility. Their mothers are in their fifties, a period of increased risk for breast cancer,” says Professor Plante. This is why the team is currently studying endocrine disruptors related to a predisposition to breast cancer, funded by the Breast Cancer Foundation and the Cancer Research Society.
Debate over legislation
In all three studies, most of the effects were observed when subjects were exposed to the lowest dose, from dust, and not the higher doses. This observation raises questions about the current legislation for endocrine disruptors. “To evaluate the “safe” dose, experts give an increasing dose and then, when they observe an effect, identify it as the maximum dose. With endocrine disruptors, the long-term consequences would be caused by lower doses” reports Professor Plante.
Although counter-intuitive, this observation comes from the fact that high doses trigger a toxic response in the cells. When the body is exposed to lower doses, similar to the concentration of hormones in our body, the consequences rather consist in the deregulation of the hormonal system.
Materials provided by Institut National de la Recherche Scientifique – INRS. Content may be edited for clarity, style, and length.