Blocking cancer-specific mutations in leukemia and brain tumors

© Stefan Pusch/DKFZ
© Stefan Pusch/DKFZ

The substitution of a single amino acid in a metabolic enzyme can be the cause of various types of cancer. Scientists from the German Cancer Research Center (DKFZ) and Heidelberg University Hospital, collaborating with Bayer AG, have now been able to develop a candidate for an agent that is intended to specifically block the altered enzyme. First studies in mice have demonstrated preclinical effects of this investigational compound. …

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