New insights reveal how house dust mites trigger allergic asthma by activating the immune system
New research in mice uncovers how inhaled house dust mites, a common trigger of allergic asthma, activate the immune system and drive this disease. …
Innovative immunotherapy strategy revives exhausted T cells by blocking cancer byproducts
New research shows that blocking the protein responsible for lactic acid uptake in exhausted T cells revitalizes their energy and enhances tumor control in mouse cancer models. …
Novel combination immunotherapy shows promise in treating melanoma
A phase 2 clinical trial found that pre-surgery treatment with the novel drug vidutolimod and the PD-1 checkpoint inhibitor nivolumab led to tumor control in 55 percent of patients with stage 3 cutaneous melanoma. …
Study identifies potential new treatment for liver fibrosis
New research sheds light on the processes that lead to liver fibrosis and suggests a novel treatment approach for this serious and common condition. …
Two new studies show how immunotherapies collaborate to boost T cell responses in melanoma
Two studies reveal that immunotherapies targeting the immune checkpoints PD1 and LAG3 work in tandem to enhance immune responses, explaining the improved outcomes for melanoma patients using combination therapies that target both checkpoints. …
Eating too much protein is bad for your arteries
Study shows that consuming over 22% of dietary calories from protein can lead to increased activation of immune cells that play a role in atherosclerotic plaque formation, driving the disease risk. …
Short-term use of immunosuppressants not linked to cancer risk
A retrospective cohort study finds that relatively short-term use of immunosuppressants to control an inflammatory disease is not associated with an increased risk of developing cancer. …
Oncolytic virus ‘warms up’ cold tumors and improves immunotherapy
Equipping oncolytic viruses with tumor-inhibiting genetic cargo stimulates the immune system and helps immunotherapy shrink or completely clear aggressive tumors in mice. …
New machine learning tool beats standard approaches for detecting heart attacks
A new machine learning model uses electrocardiogram (ECG) readings to diagnose and classify heart attacks faster and more accurately than current approaches. …
Diet and probiotic bacteria boost melanoma immunotherapy response
In mice with melanoma, probiotic bacteria travel from the gut and establish in tumors, where they directly stimulate immune cells to make cancer immunotherapy more effective. …
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