Age-related changes in fibroblast cells promote pancreatic cancer growth and spread
New research shows that aging alters pancreatic fibroblasts in ways that enable them to promote pancreatic cancer tumor growth. …
Natural compounds derived from soy and other plants reduce breast cancer recurrence and improve survival
Systematic review and meta-analysis of observational studies suggest that phytonutrients derived from soy, green tea, and other plants significantly reduce the risks in breast cancer outcomes. …
Protein mutation creates ‘super’ T cells with potential to fight off cancer and infections
Modifying a specific protein in T cells can make them more robust, potentially improving cancer immunotherapy. …
Researchers develop gut-restricted drug to treat inflammatory bowel disease
An experimental drug that inhibits a gut enzyme protects mice from inflammatory bowel disease (IBD) symptoms and preserves barrier function in intestinal “organoids” derived from IBD patients. …
New machine-learning method may aid personalized cancer immunotherapies
Deep-learning technology can accurately predict cancer-related protein fragments that may trigger an immune system response, which could overcome a major hurdle to developing personalized cancer immunotherapies and vaccines. …
Three-pronged combination immunotherapy sparks immune response in pancreatic cancers
Giving patients with operable pancreatic cancer a three-pronged combination immunotherapy treatment increases the amount of cancer-killing T cells in the tumors and appears effective when given prior to cancer-removal surgery. …
Preclinical study supports use of green tea compound EGCG as treatment for uterine fibroids
Preclinical study finds that epigallocatechin gallate (EGCG), a green tea compound with powerful antioxidant properties, could be promising for both treating and preventing uterine fibroids. …
Preclinical studies advance potential new target to treat HIV infection
Two new studies in mice with a humanized immune system and human cell lines have identified an enzyme that plays a critical role in the late stages of HIV replication. …
Mitochondrial DNA fragments in blood as biomarkers for aging and inflammation
High levels of cell-free DNA circulating in blood is further linked to chronic inflammation, a well-known risk factor for severe aging symptoms and frailty in older adults. …
‘Tipping the balance’ of immune cells from bad to good reverses multiple sclerosis symptoms in mice
A microparticle-delivered therapy may be first step toward stopping multiple sclerosis and other autoimmune diseases. …
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